Research interests

21st Century Medicinal Chemistry: Advancing Antifungal Therapy through Molecular Design
Medicinal chemistry has undergone significant transformations in the 21st century, revolutionizing the way we approach drug discovery and development. With advancements in scientific knowledge, technology, and computational tools, medicinal chemists are now equipped with unprecedented resources to create innovative and targeted therapeutics. Medicinal chemistry depends on careful molecular design, rationally designed drug molecules by precisely understanding the underlying biological mechanisms and structural interactions in the host.

We are Medicinal Chemistry Research Group oriented towards Antifungal Compounds, Drug Delivery through designer Self-Immolative Linkers, and Phosphorus Chemistry. We welcome collaborations, partnerships, and discussions to further our collective efforts in these dynamic research areas. Please feel free to reach out to us with any inquiries or opportunities that align with our research goals.

Designing Antifungal Compounds

With the rise in novel pathogenic fungal infections, increasing resistance of fungal pathogens, and the urgent need for effective antifungal treatments, our research group has made it our mission to unravel novel antifungal compounds. We employ state-of-the-art techniques, including photochemistry, electrochemistry, and modern medicinal chemistry, to identify and design potent antifungal agents. Our goal is to develop new drugs, or to alter the structure of old drugs, that will exhibit enhanced efficacy, reduced side effects, and posses a greater spectrum of activity against fungal pathogens.

Drug Delivery through designer Self-Immolative Linkers

Ensuring efficient delivery of drugs to their intended targets is crucial for successful treatments. We explore various delivery mechanisms, including target engagement, target recognition, and self-immolative linkers, with the aim of enhancing drug stability, selectivity, and targeted release. By harnessing innovative chemical approaches, we aim to design smart linkers capable of responding to specific stimuli, such as pH changes, enzyme activity, or light irradiation. Our vision is to develop self-immolative linkers that enhance the efficacy and precision of drug delivery systems, allowing for spatiotemporal control over drug release.

Phosphorus Chemistry

Another essential aspect of our research group's focus lies in the vibrant field of phosphorus chemistry. Phosphorus-containing compounds find extensive applications in drug synthesis, catalysis, materials science, and bioimaging. By employing advanced synthetic methodologies, we strive to unlock the full potential of phosphorus-based molecules, developing new strategies for their synthesis and utilization in various applications. Our research paves the way for the development of innovative phosphorus-based compounds with diverse functional properties.